6-Chloro-4-methylpyridine-3-sulfonyl chloride

Name: 6-Chloro-4-methylpyridine-3-sulfonyl chloride
Brand: ChemScene
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CAS No. 889944-76-7
Cat. No. CS-W022486
Purity≥97%
MDL No.MFCD08436478

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-4-methylpyridine-3-sulfonyl chloride|CS-W022486

Structure of 889944-76-7

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General Information

CAS No. 889944-76-7
Cat. No. CS-W022486
Purity ≥97%
MDL No. MFCD08436478
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅Cl₂NO₂S
Molecular Weight 226.08
Synonym(s) 6-Chloro-4-methyl-pyridine-3-sulfonyl chloride
SMILES O=S(C1=C(C)C=C(Cl)N=C1)(Cl)=O

Description

6-Chloro-4-methylpyridine-3-sulfonyl chloride features a reactive sulfonyl chloride group flanked by electron-withdrawing chlorine and methyl substituents, enabling selective acylation in synthetic routes. The pyridine scaffold enhances regioselectivity in nucleophilic substitution, while the bench-stable nature facilitates handling under standard conditions. This reagent streamlines the incorporation of sulfonyl moieties into complex molecular architectures.

Application

6-Chloro-4-methylpyridine-3-sulfonyl chloride serves as a versatile sulfonyl chloride building block for the synthesis of sulfonamide-containing compounds. Its reactivity enables efficient coupling with amines under mild conditions, facilitating rapid access to functionalized pyridine scaffolds. The chloro and methyl substituents provide orthogonal handles for further derivatization, while the sulfonyl chloride group offers excellent bench stability and ease of purification in standard synthetic workflows.

Synthesis

Route1
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  66909-38-4
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  889944-76-7
References
- ELAN PHARMACEUTICALS, INC. Patent: WO2003/93245 A1, 2003 ; Location in patent: Page/Page column 204-205 ; WO 03/093245 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 47.03
LogP 1.97092
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-4-methylpyridine-3-sulfonyl chloride

CAS No. 889944-76-7

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