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CS-W001157 4
Total: USD 88.00

2,6-Difluoroisonicotinic acid

  • CAS No. 88912-23-6

  • Cat. No. CS-0112555
  • Purity≥98%
  • MDL No.MFCD09864665

*For research and further manufacturing use only, not for direct human use.

2,6-Difluoroisonicotinic acid|CS-0112555

Structure of 88912-23-6

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General Information

  • CAS No. 88912-23-6
  • Cat. No. CS-0112555
  • Purity ≥98%
  • MDL No. MFCD09864665
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂NO₂
  • Molecular Weight 159.09
  • Synonym(s) 2,6-Difluoropyridine-4-carboxylic acid
  • SMILES O=C(C1=CC(F)=NC(F)=C1)O

Description

2,6-Difluoroisonicotinic acid features a fluorinated pyridine core with strategically positioned electron-withdrawing substituents. This configuration enhances metabolic stability and modulates electronic properties for use in pharmaceutical intermediates and agrochemical scaffolds. The compound exhibits robust bench stability and facilitates efficient coupling reactions under standard conditions.

Application

2,6-Difluoroisonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive molecules. Its ortho-fluorine substituents enhance metabolic stability and modulate electronic properties, while the carboxylic acid group facilitates direct coupling reactions or derivatization. The compound exhibits good bench stability and compatibility with standard amide bond formation protocols, making it well-suited for parallel library synthesis and API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.058
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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