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Structure of 887707-25-7
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2-Chloro-5-iodo-3-(trifluoromethyl)pyridine is a halogenated pyridine scaffold featuring orthogonal reactive sites for cross-coupling. The trifluoromethyl group imparts enhanced electron-withdrawing character and metabolic stability, while the chloro and iodo substituents enable sequential functionalization via palladium-catalyzed transformations. This compound serves as a key building block in the synthesis of bioactive heterocycles and pharmaceutical intermediates.
2-Chloro-5-iodo-3-(trifluoromethyl)pyridine serves as a versatile building block in cross-coupling chemistry, enabling the construction of complex heterocyclic scaffolds via Pd-catalyzed reactions. The orthogonal reactivity of the chloro and iodo substituents facilitates sequential functionalization, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. Bench-stable and readily purified by flash chromatography, it functions reliably in standard coupling protocols for API development and advanced synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: