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CS-W001157 4
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Methyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate

  • CAS No. 88738-78-7

  • Cat. No. CS-0150676
  • Molecule weight318.11
  • Purity≥95%
  • MDL No.MFCD00009901

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate|CS-0150676

Structure of 88738-78-7

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General Information

  • CAS No. 88738-78-7
  • Cat. No. CS-0150676
  • Purity ≥95%
  • MDL No. MFCD00009901
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉F₆O₅P
  • Molecular Weight 318.11
  • Synonym(s) methyl P,P-bis(2,2,2-trifluoroethyl) phosphonoacetate
  • SMILES COC(=O)CP(=O)(OCC(F)(F)F)OCC(F)(F)F

Description

MethylP,P-bis(2,2,2-trifluoroethyl)phosphonoacetate can be used:In one of the key synthetic steps for the preparation oftrans-hydrindanes and (R)-(+)-umbelactone.To prepare a cis-olefinic ester derivative by StillGennari olefination of an aldehyde derivative using 18-crown ether and potassium bis(trimethylsilyl)amide (KHMDS).In the synthesis of ()-(6S,2S)-epicryptocaryalactone.

Synthesis

  • Route1
    • null|null
      75-89-8
    • null|null
      31460-11-4
    • ~%
    • In-stock
      Methyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate|CS-0150676
      88738-78-7

    References

    • Messik, Frauke; Oberthuer, Markus Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-T0771-PSP, p. 167 - 170
  • Route2
    • null|null
      75-89-8
    • null|null
      31460-11-4
    • ~38%
    • In-stock
      Methyl 2-(bis(2,2,2-trifluoroethoxy)phosphoryl)acetate|CS-0150676
      88738-78-7
    • null|null
      681123-85-3

    References

    • Still, W. Clark; Gennari, Cesare Tetrahedron Letters, 1983 , vol. 24, # 41 p. 4405 - 4408

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.83
  • LogP   2.5103
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   6

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