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CS-W001157 4
Total: USD 88.00

2-(4-Fluoro-2-methoxyphenyl)acetic acid

  • CAS No. 886498-61-9

  • Cat. No. CS-0460992
  • Purity≥97%
  • MDL No.MFCD06660193

*For research and further manufacturing use only, not for direct human use.

2-(4-Fluoro-2-methoxyphenyl)acetic acid|CS-0460992

Structure of 886498-61-9

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General Information

  • CAS No. 886498-61-9
  • Cat. No. CS-0460992
  • Purity ≥97%
  • MDL No. MFCD06660193
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO₃
  • Molecular Weight None
  • Synonym(s) (4-Fluoro-2-methoxyphenyl)acetic acid
  • SMILES COC1=C(C=CC(=C1)F)CC(=O)O

Description

This 2-(4-fluoro-2-methoxyphenyl)acetic acid features a fluorinated aromatic ring paired with a methoxy substituent, delivering enhanced lipophilicity and metabolic stability. The carboxylic acid group enables direct conjugation or derivatization in medicinal chemistry applications.

Application

2-(4-Fluoro-2-methoxyphenyl)acetic acid serves as a versatile building block for pharmaceutical intermediates, enabling efficient access to bioactive heterocycles and aryl-substituted carboxylic acid scaffolds. Its ortho-methoxy and para-fluoro substituents provide enhanced metabolic stability and favorable electronic properties for downstream functionalization. The compound exhibits excellent bench stability, facilitates straightforward purification via crystallization, and participates reliably in standard amide coupling, esterification, and Suzuki-Miyaura cross-coupling reactions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   1.4614
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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