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Structure of 886369-02-4
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2-(3-Bromophenyl)thiazole-4-carboxylic acid features a brominated phenyl ring fused to a thiazole core, delivering enhanced electron-withdrawing character and improved solubility in polar solvents. This scaffold enables direct incorporation into bioactive molecules, particularly in kinase inhibitors and pharmaceutical intermediates. The carboxylic acid group facilitates coupling reactions under standard amide formation conditions.
2-(3-Bromophenyl)thiazole-4-carboxylic acid serves as a versatile building block for the synthesis of biologically relevant heterocycles and pharmaceutical intermediates. Its structure combines a brominated phenyl group with a thiazole carboxylic acid moiety, enabling facile Suzuki-Miyaura and other Pd-catalyzed couplings. The carboxylic acid functionality offers direct access to amides, esters, and other derivatives, facilitating downstream functionalization in medicinal chemistry campaigns. The compound exhibits good bench stability and is readily purified by recrystallization or chromatography.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: