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CS-W001157 4
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1-(m-Tolyl)cyclopropanecarboxylic acid

  • CAS No. 886366-16-1

  • Cat. No. CS-0088464
  • Molecule weight176.21
  • Purity≥98%
  • MDL No.MFCD07374445

*For research and further manufacturing use only, not for direct human use.

1-(m-Tolyl)cyclopropanecarboxylic acid|CS-0088464

Structure of 886366-16-1

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General Information

  • CAS No. 886366-16-1
  • Cat. No. CS-0088464
  • Purity ≥98%
  • MDL No. MFCD07374445
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O₂
  • Molecular Weight 176.21
  • Synonym(s) 1-M-TOLYLCYCLOPROPANECARBOXYLIC ACID
  • SMILES OC(C1(C2=CC=CC(C)=C2)CC1)=O

Description

This cyclopropanecarboxylic acid derivative features a meta-tolyl substituent that enhances aromatic character and steric bulk. The strained cyclopropane ring imparts unique reactivity, while the carboxylic acid group enables direct functionalization or coupling in synthetic sequences. Bench-stable and moisture-tolerant, it serves as a valuable scaffold for medicinal chemistry and materials synthesis.

Application

1-(m-Tolyl)cyclopropanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and constrained scaffolds. Its cyclopropane ring imparts structural rigidity, while the carboxylic acid functionality facilitates straightforward derivatization via amide, ester, or acyl chloride formation. The meta-tolyl substituent enhances lipophilicity and offers favorable steric profiles for target engagement, making it a practical choice for lead optimization campaigns requiring stable, synthetically accessible intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.11122
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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