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Structure of 1557661-16-1
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2-Cyclopropyl-2,2-difluoroacetic acid features a sterically hindered cyclopropyl group paired with a geminal difluoro motif, delivering enhanced metabolic stability and lipophilicity. This structural combination enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry applications requiring resistance to oxidative degradation. The compound exhibits bench-stable handling characteristics under standard conditions.
2-Cyclopropyl-2,2-difluoroacetic acid serves as a versatile building block in medicinal chemistry, enabling the introduction of a sterically constrained, highly lipophilic difluoromethyl group. Its stability under standard synthetic conditions facilitates incorporation into bioactive molecules via esterification, amidation, or direct functionalization. The cyclopropyl moiety enhances metabolic resistance and modulates conformational flexibility, making it valuable for optimizing pharmacokinetic profiles in drug discovery campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P264-P270-P330
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Lot numbers can be found on the outside label of a product: