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CS-W001157 4
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5-Chloro-3-methylpyridine-2-carboxylic acid

  • CAS No. 886365-46-4

  • Cat. No. CS-W003405
  • Purity≥97%
  • MDL No.MFCD07375127

*For research and further manufacturing use only, not for direct human use.

5-Chloro-3-methylpyridine-2-carboxylic acid|CS-W003405

Structure of 886365-46-4

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General Information

  • CAS No. 886365-46-4
  • Cat. No. CS-W003405
  • Purity ≥97%
  • MDL No. MFCD07375127
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) 5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID
  • SMILES O=C(C1=NC=C(Cl)C=C1C)O

Description

5-Chloro-3-methylpyridine-2-carboxylic acid features a pyridine core functionalized with chlorine, methyl, and carboxylic acid groups at strategic positions. This electron-deficient scaffold enables direct incorporation into bioactive molecules and pharmaceutical intermediates. The carboxylic acid moiety facilitates derivatization under standard coupling conditions. The compound exhibits bench-stable handling and compatibility with diverse synthetic transformations.

Application

5-Chloro-3-methylpyridine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through established functional group transformations. Its ortho-carboxylic acid and meta-chloro substituents provide orthogonal reactivity for coupling, derivatization, and cyclization processes. Bench-stable and amenable to standard purification methods, it functions reliably in the synthesis of pharmaceutical intermediates and agrochemical scaffolds.

Synthesis

  • Route1
    • In-stock
      2,5-Dichloropyridine|CS-W016342
      16110-09-1
    • null|null
      67-56-1
    • null|null
      201230-82-2
    • ~97%
    • In-stock
      5-Chloro-3-methylpyridine-2-carboxylic acid|CS-W003405
      886365-46-4

    References

    • Albaneze-Walker, Jennifer; Ceglia, Scott; Murry, Jerry Anthony; Soheili, Arash Patent: US2004/102472 A1, 2004 ; Location in patent: Page 49; 50 ; US 20040102472 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.74162
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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