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CS-W001157 4
Total: USD 88.00

4-Bromo-6-fluoro-1H-indole

  • CAS No. 885520-70-7

  • Cat. No. CS-W019334
  • Purity≥97%
  • MDL No.MFCD08272203

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-fluoro-1H-indole|CS-W019334

Structure of 885520-70-7

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General Information

  • CAS No. 885520-70-7
  • Cat. No. CS-W019334
  • Purity ≥97%
  • MDL No. MFCD08272203
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrFN
  • Molecular Weight 214.04
  • Synonym(s) 4-Bromo-6-fluoroindole
  • SMILES FC1=CC2=C(C(Br)=C1)C=CN2

Description

4-Bromo-6-fluoro-1H-indole features a strategically positioned bromo and fluoro substituent on the indole core, enabling direct functionalization in cross-coupling reactions. The electron-deficient aromatic system enhances reactivity in palladium-catalyzed transformations, while the bench-stable crystalline form simplifies handling and storage. This compound serves as a key building block for bioactive heterocycles in medicinal chemistry.

Application

4-Bromo-6-fluoro-1H-indole serves as a valuable building block in medicinal chemistry, enabling direct functionalization at the C4 and C6 positions for diversification. Its halogenated framework supports palladium-catalyzed cross-coupling reactions, facilitating the construction of complex indole-based scaffolds. The molecule exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      1093066-65-9
    • ~37%
    • In-stock
      4-Bromo-6-fluoro-1H-indole|CS-W019334
      885520-70-7

    References

    • F.HOFFMANN-LA ROCHE AG Patent: WO2009/53716 A1, 2009 ; Location in patent: Page/Page column 56 ; WO 2009/053716 A1
  • Route2

    References

    • BIOVITRUM AB (publ) Patent: WO2008/3703 A1, 2008 ; Location in patent: Page/Page column 91 ; WO 2008/003703 A1
  • Route3
    • null|null
      1181566-93-7
    • ~%
    • In-stock
      4-Bromo-6-fluoro-1H-indole|CS-W019334
      885520-70-7

    References

    • WO2009/103710 A1, ; Page/Page column 21 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   3.0695
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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