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Methyl 4-chloro-1H-indazole-6-carboxylate

  • CAS No. 885519-19-7

  • Cat. No. CS-0131072
  • Purity≥97%
  • MDL No.MFCD07781359

*For research and further manufacturing use only, not for direct human use.

Methyl 4-chloro-1H-indazole-6-carboxylate|CS-0131072

Structure of 885519-19-7

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General Information

  • CAS No. 885519-19-7
  • Cat. No. CS-0131072
  • Purity ≥97%
  • MDL No. MFCD07781359
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClN₂O₂
  • Molecular Weight 210.62
  • Synonym(s) Methyl 4-Chloro-indazole -6-carboxylate
  • SMILES O=C(C1=CC2=C(C(Cl)=C1)C=NN2)OC

Description

Methyl 4-chloro-1H-indazole-6-carboxylate is a bench-stable heterocyclic ester featuring a chlorinated indazole core. This electron-deficient scaffold integrates readily into medicinal chemistry campaigns, serving as a key intermediate for C–H functionalization and Suzuki-Miyaura coupling reactions. The methyl ester group enables straightforward derivatization under mild conditions.

Application

Methyl 4-chloro-1H-indazole-6-carboxylate serves as a versatile building block for the synthesis of indazole-based pharmaceuticals and agrochemicals. The chloro group at the 4-position enables palladium-catalyzed cross-coupling reactions, while the ester functionality supports selective reduction or hydrolysis. Its bench-stable nature and compatibility with diverse reaction conditions facilitate efficient access to functionalized indazole scaffolds in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   54.98
  • LogP   2.0029
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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