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CS-W001157 4
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3-Bromo-2-nitropyridine

  • CAS No. 54231-33-3

  • Cat. No. CS-W002706
  • Purity≥97%
  • MDL No.MFCD00955614

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-nitropyridine|CS-W002706

Structure of 54231-33-3

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General Information

  • CAS No. 54231-33-3
  • Cat. No. CS-W002706
  • Purity ≥97%
  • MDL No. MFCD00955614
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrN₂O₂
  • Molecular Weight 202.99
  • Synonym(s) IFLAB-BB F1371-0193
  • SMILES O=[N+](C1=NC=CC=C1Br)[O-]

Description

3-Bromo-2-nitropyridine features a bromine atom at the 3-position and a nitro group at the 2-position of the pyridine ring, creating a highly functionalized heterocycle. This electronic asymmetry enables selective cross-coupling reactions and facilitates downstream derivatization in medicinal chemistry and materials synthesis. The compound exhibits good stability under standard conditions and serves as a key intermediate for advanced nitrogen-containing architectures.

Application

3-Bromo-2-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions and nucleophilic substitution processes. The bromo group facilitates efficient C–C bond formation, while the nitro functionality provides a handle for selective reduction or further functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for constructing complex pyridine-based scaffolds in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.7523
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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