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CS-W001157 4
Total: USD 88.00

2-(3-Bromophenyl)-2,2-difluoroacetic acid

  • CAS No. 885068-76-8

  • Cat. No. CS-0046055
  • Purity≥96%
  • MDL No.MFCD11167799
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(3-Bromophenyl)-2,2-difluoroacetic acid|CS-0046055

Structure of 885068-76-8

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Description

This fluorinated arylacetic acid features a brominated phenyl ring conjugated to a difluoromethyl group, delivering enhanced metabolic stability and electron-withdrawing character. The para-bromine substitution enables efficient coupling in cross-coupling protocols, while the geminal difluoride imparts increased lipophilicity and resistance to enzymatic degradation. This compound serves as a key building block for bioactive molecule synthesis.

Application

2-(3-Bromophenyl)-2,2-difluoroacetic acid serves as a versatile building block for fluorinated aromatic systems, enabling efficient incorporation of difluoromethyl and bromophenyl moieties into pharmaceutical and agrochemical scaffolds. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate C–C bond formation under standard conditions. The molecule’s functional group tolerance supports downstream derivatization in medicinal chemistry workflows.

General Information

  • CAS No. 885068-76-8
  • Cat. No. CS-0046055
  • Purity ≥96%
  • MDL No. MFCD11167799
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrF₂O₂
  • Molecular Weight 251.02
  • Synonym(s) (3-Bromophenyl)(difluoro)acetic acid
  • SMILES O=C(O)C(F)(F)C1=CC=CC(Br)=C1

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.6255
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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