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CS-W001157 4
Total: USD 88.00

sec-Butylboronic acid

  • CAS No. 88496-88-2

  • Cat. No. CS-W011315
  • Purity≥97%
  • MDL No.MFCD06656265

*For research and further manufacturing use only, not for direct human use.

sec-Butylboronic acid|CS-W011315

Structure of 88496-88-2

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General Information

  • CAS No. 88496-88-2
  • Cat. No. CS-W011315
  • Purity ≥97%
  • MDL No. MFCD06656265
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₁BO₂
  • Molecular Weight 101.94
  • Synonym(s) Buntane-2-boronic acid
  • SMILES CCC(B(O)O)C

Description

sec-Butylboronic acid offers a sterically hindered boronate handle ideal for Suzuki-Miyaura cross-coupling reactions. This bench-stable reagent integrates efficiently into complex molecular architectures, enabling reliable C–C bond formation under mild conditions. The secondary carbon center enhances regioselectivity in transition-metal-catalyzed transformations.

Application

sec-Butylboronic acid serves as a reliable building block in Suzuki-Miyaura cross-coupling reactions, offering good bench stability and compatibility with diverse functional groups. Its moderate steric profile enables efficient coupling with aryl and vinyl halides, facilitating the construction of complex biaryl and styrenyl architectures common in pharmaceutical intermediates. The reagent is readily purified by recrystallization and handles well under standard laboratory conditions.

Synthesis

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    • ~%
    • In-stock
      sec-Butylboronic acid|CS-W011315
      88496-88-2

    References

    • Journal of the American Chemical Society, , vol. 79, p. 5179

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.2593
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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