2-chloro-5-fluoropyridin-3-amine

Name: 2-chloro-5-fluoropyridin-3-amine
Brand: ChemScene
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CAS No. 884495-37-8
Cat. No. CS-0005591
Purity≥98%
MDL No.MFCD08277275

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-chloro-5-fluoropyridin-3-amine|CS-0005591

Structure of 884495-37-8

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Description

2-Chloro-5-fluoropyridin-3-amine features a dual halogenated pyridine core with orthogonal reactivity, enabling selective coupling in late-stage functionalization. The electron-deficient ring and amine handle facilitate efficient incorporation into pharmaceutical scaffolds, particularly in kinase inhibitors and antiviral agents.

Application

2-Chloro-5-fluoropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based heterocycles. Its orthogonal reactivity—where the amine group facilitates nucleophilic substitution while the chloro and fluoro substituents support palladium-catalyzed coupling—makes it ideal for modular synthesis of API candidates. Bench-stable and readily purified, it functions reliably in standard cross-coupling and cyclization workflows.

General Information

CAS No. 884495-37-8
Cat. No. CS-0005591
Purity ≥98%
MDL No. MFCD08277275
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄ClFN₂
Molecular Weight 146.55
Synonym(s) 3-PyridinaMine,2-chloro-5-fluoro-
SMILES NC1=CC(F)=CN=C1Cl

Computational Chemistry Data

TPSA 38.91
LogP 1.4563
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2-chloro-5-fluoropyridin-3-amine

CAS No. 884495-37-8

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