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CS-W001157 4
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3-Iodo-6-methylpyridin-2-amine

  • CAS No. 884495-19-6

  • Cat. No. CS-0041758
  • Molecule weight234.04
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Iodo-6-methylpyridin-2-amine|CS-0041758

Structure of 884495-19-6

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General Information

  • CAS No. 884495-19-6
  • Cat. No. CS-0041758
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇IN₂
  • Molecular Weight 234.04
  • Synonym(s) 3-iodo-6-methylpyridin-2-ylamine
  • SMILES NC1=NC(C)=CC=C1I

Description

3-Iodo-6-methylpyridin-2-amine delivers a reactive iodine handle and electron-rich pyridine core, enabling efficient cross-coupling in late-stage functionalization. The methyl group enhances solubility and steric profile, while the amine moiety provides a site for derivatization. This compound serves as a key scaffold in medicinal chemistry for constructing bioactive heterocycles under standard conditions.

Application

3-Iodo-6-methylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive iodide group and electron-rich pyridine scaffold. The methyl and amino substituents provide orthogonal functional handles for further derivatization, while the compound exhibits excellent bench stability and compatibility with standard purification methods.

Synthesis

  • Route1

    References

    • Synlett, , # 2 p. 208 - 214
  • Route2

    References

    • Shen, Hao; Vollhardt, K. Peter C. Synlett, 2012 , # 2 p. 208 - 214

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.57682
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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