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CS-W001157 4
Total: USD 88.00

5-Bromo-2-chloro-4-methyl-3-nitropyridine

  • CAS No. 884495-15-2

  • Cat. No. CS-W010207
  • Purity≥95%
  • MDL No.MFCD06659505

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-chloro-4-methyl-3-nitropyridine|CS-W010207

Structure of 884495-15-2

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General Information

  • CAS No. 884495-15-2
  • Cat. No. CS-W010207
  • Purity ≥95%
  • MDL No. MFCD06659505
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrClN₂O₂
  • Molecular Weight 251.47
  • Synonym(s) 5-Bromo-2-Chloro-3-Nitro-4-Picoline
  • SMILES O=[N+](C1=C(C)C(Br)=CN=C1Cl)[O-]

Description

5-Bromo-2-chloro-4-methyl-3-nitropyridine features a densely functionalized pyridine core with complementary electrophilic sites. The nitro group at C3 enhances reactivity for nucleophilic substitution, while the bromo and chloro substituents enable cross-coupling transformations. The methyl group provides steric and electronic modulation. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and advanced pharmaceutical scaffolds under standard conditions.

Application

5-Bromo-2-chloro-4-methyl-3-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its dual halogen functionality. The nitro group facilitates electrophilic substitution and subsequent reduction to an amine, while the methyl group provides a site for oxidation or functionalization. Its stability under standard reaction conditions and compatibility with diverse coupling partners make it valuable for constructing complex pyridine-based scaffolds in medicinal chemistry and agrochemical development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   2.71412
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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