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CS-W001157 4
Total: USD 88.00

2-Chloro-4-methyl-3-nitropyridine

  • CAS No. 23056-39-5

  • Cat. No. CS-W020672
  • Purity≥97%
  • MDL No.MFCD00012347

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-methyl-3-nitropyridine|CS-W020672

Structure of 23056-39-5

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General Information

  • CAS No. 23056-39-5
  • Cat. No. CS-W020672
  • Purity ≥97%
  • MDL No. MFCD00012347
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClN₂O₂
  • Molecular Weight 172.57
  • Synonym(s) None
  • SMILES O=[N+](C1=C(C)C=CN=C1Cl)[O-]

Description

2-Chloro-4-methyl-3-nitropyridine features a strategically positioned nitro group and chloro substituent on the pyridine core, enabling selective functionalization in cross-coupling reactions. The methyl group enhances electron density at C4, while the electron-deficient ring facilitates nucleophilic substitution. This bench-stable compound serves as a key intermediate in medicinal chemistry for constructing heterocyclic scaffolds.

Synthesis

  • Route1

    References

    • Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Techasakul, Supanna; Thitithanyanont, Arunee; Saparpakorn, Patchreenart; Hannongbua, Supa; Choowongkomon, Kiattawee; Pungpo, Pornpan Beilstein Journal of Organic Chemistry, 2009 , vol. 5, art. no. A36
  • Route2

    References

    • Linz, Sabine; Mueller, Joerg; Huebner, Harald; Gmeiner, Peter; Troschuetz, Reinhard Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4448 - 4458
  • Route3
    • In-stock
      2-Hydroxy-4-methyl-3-nitropyridine|CS-W008349
      21901-18-8
    • null|null
      10026-13-8
    • ~%
    • In-stock
      2-Chloro-4-methyl-3-nitropyridine|CS-W020672
      23056-39-5

    References

    • US5366972 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.95162
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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