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Structure of 884495-14-1
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5-Bromo-2-methoxy-3-nitro-4-picoline features a strategically positioned bromine atom flanked by electron-withdrawing nitro and methoxy groups, enabling selective cross-coupling reactions. The para-nitro substitution enhances electrophilicity at the 4-position, while the methoxy group improves solubility and modulates reactivity in transition metal-catalyzed transformations. This scaffold serves as a high-value building block for complex heterocyclic architectures in medicinal chemistry and materials science.
5-Bromo-2-methoxy-3-nitro-4-picoline serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the pyridine ring due to orthogonal reactivity of bromo, methoxy, and nitro groups. Its stability under standard reaction conditions facilitates palladium-catalyzed cross-coupling, nucleophilic substitution, and selective reduction sequences, making it valuable for constructing complex nitrogen-containing scaffolds in medicinal chemistry and agrochemical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: