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Structure of 884494-70-6
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2-Chloro-4-methylpyridin-3-ol features a pyridin-3-ol core with strategically positioned chloro and methyl groups, enabling selective nucleophilic substitution. The electron-deficient ring facilitates coupling reactions, while the phenolic OH offers hydrogen-bonding capacity. This scaffold integrates readily into bioactive molecules and serves as a key intermediate in agrochemical and pharmaceutical synthesis under standard conditions.
2-Chloro-4-methylpyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via nucleophilic substitution. Its chloro group exhibits high reactivity toward amines, thiols, and other nucleophiles under mild conditions, facilitating rapid diversification. The pyridinol functionality provides hydrogen-bonding capability and enhances solubility, while the methyl group offers modest steric influence. Bench-stable and readily purified by recrystallization or chromatography, it functions reliably in standard coupling workflows for API intermediate synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: