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(3,3-Difluorocyclopentyl)methanol

  • CAS No. 883731-63-3

  • Cat. No. CS-0053393
  • Molecule weight136.14
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3,3-Difluorocyclopentyl)methanol|CS-0053393

Structure of 883731-63-3

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General Information

  • CAS No. 883731-63-3
  • Cat. No. CS-0053393
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀F₂O
  • Molecular Weight 136.14
  • Synonym(s) 3,3-Difluoro-cyclopentanemethanol - D11725
  • SMILES OCC1CCC(F)(F)C1

Description

(3,3-Difluorocyclopentyl)methanol features a rigid cyclopentane core bearing two fluorine atoms at the 3-position, enhancing metabolic stability and lipophilicity. The pendant hydroxymethyl group provides a versatile handle for derivatization, enabling integration into bioactive molecules where controlled solubility and membrane permeability are critical.

Application

(3,3-Difluorocyclopentyl)methanol serves as a valuable building block in medicinal chemistry, offering a rigid, fluorinated cyclopentane scaffold with enhanced metabolic stability. The primary alcohol enables straightforward functionalization via esterification, etherification, or oxidation to the aldehyde. Its difluoro substitution pattern enhances lipophilicity and modulates electronic properties, while the molecule exhibits good bench stability and compatibility with standard synthetic transformations.

Synthesis

  • Route1

    References

    • SANOFI-AVENTIS Patent: US2009/325942 A1, 2009 ; Location in patent: Page/Page column 55 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.4141
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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