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CS-W001157 4
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Methyl 3-amino-2,6-dichloroisonicotinate

  • CAS No. 883107-62-8

  • Cat. No. CS-0019346
  • Purity≥97%
  • MDL No.MFCD07437844

*For research and further manufacturing use only, not for direct human use.

Methyl 3-amino-2,6-dichloroisonicotinate|CS-0019346

Structure of 883107-62-8

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General Information

  • CAS No. 883107-62-8
  • Cat. No. CS-0019346
  • Purity ≥97%
  • MDL No. MFCD07437844
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆Cl₂N₂O₂
  • Molecular Weight 221.04
  • Synonym(s) Methyl 3-amino-2,6-dichloropyridine-4-carboxylate
  • SMILES O=C(C1=C(N)C(Cl)=NC(Cl)=C1)OC

Description

Methyl 3-amino-2,6-dichloroisonicotinate features a pyridine core with strategic chlorine substitutions and a terminal amino group, enabling direct incorporation into bioactive heterocycles. This bench-stable derivative facilitates rapid diversification in medicinal chemistry campaigns, particularly for kinase inhibitors and antimicrobial agents, due to its compatibility with cross-coupling and nucleophilic substitution reactions under standard conditions.

Application

Methyl 3-amino-2,6-dichloroisonicotinate serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine scaffolds via standard coupling and cyclization protocols. The molecule exhibits bench stability, tolerates diverse functional groups, and facilitates efficient derivatization through its amino and ester functionalities, making it well-suited for parallel synthesis campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • WO2008/130021 A2, ; Page/Page column 394-395 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   1.7572
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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