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Structure of 881995-69-3
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(R)-methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate serves as a critical impurity reference standard in sitagliptin synthesis monitoring. This chiral intermediate features a trifluorophenyl moiety that enhances metabolic stability and contributes to the compound’s pharmacophoric integrity. The molecule exhibits bench-stable handling characteristics under standard conditions, facilitating accurate quantification in quality control workflows.
(R)-Methyl 3-amino-4-(2,4,5-trifluorophenyl)butanoate serves as a key chiral intermediate in the synthesis of sitagliptin, a DPP-4 inhibitor used in type 2 diabetes management. The molecule features a stereogenic center with defined (R)-configuration, enabling high-fidelity incorporation into the final API scaffold. Its amino and ester functionalities offer orthogonal reactivity for downstream transformations, including amidation and coupling reactions. Bench-stable under standard handling conditions, it facilitates efficient purification and consistent yield in multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: