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2,3-Dibromo-5-fluoropyridine

  • CAS No. 878207-82-0

  • Cat. No. CS-0005594
  • Molecule weight254.88
  • Purity≥98%
  • MDL No.MFCD08532501

*For research and further manufacturing use only, not for direct human use.

2,3-Dibromo-5-fluoropyridine|CS-0005594

Structure of 878207-82-0

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General Information

  • CAS No. 878207-82-0
  • Cat. No. CS-0005594
  • Purity ≥98%
  • MDL No. MFCD08532501
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Br₂FN
  • Molecular Weight 254.88
  • Synonym(s) Pyridine, 2,3-dibromo-5-fluoro-
  • SMILES FC1=CN=C(Br)C(Br)=C1

Description

2,3-Dibromo-5-fluoropyridine offers a uniquely activated pyridine scaffold for cross-coupling and functionalization. The ortho-dibromo substitution enables sequential palladium-catalyzed reactions, while the para-fluoro group provides a complementary handle for nucleophilic displacement. This combination delivers high regiocontrol in complex molecule assembly.

Application

2,3-Dibromo-5-fluoropyridine serves as a versatile building block for the synthesis of fluorinated heterocycles and pharmaceutical intermediates. The ortho-dibromo substitution enables palladium-catalyzed cross-coupling reactions, while the C5 fluorine offers a site for nucleophilic displacement or further functionalization. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for multi-step synthetic sequences in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.7457
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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