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CS-W001157 4
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2,6-Dibromo-3-fluoropyridine

  • CAS No. 41404-59-5

  • Cat. No. CS-0063834
  • Purity≥95%
  • MDL No.MFCD13185513

*For research and further manufacturing use only, not for direct human use.

2,6-Dibromo-3-fluoropyridine|CS-0063834

Structure of 41404-59-5

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General Information

  • CAS No. 41404-59-5
  • Cat. No. CS-0063834
  • Purity ≥95%
  • MDL No. MFCD13185513
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Br₂FN
  • Molecular Weight 254.88
  • Synonym(s) 2,6-Dibrom-3-fluorpyridin
  • SMILES FC1=CC=C(Br)N=C1Br

Description

2,6-Dibromo-3-fluoropyridine features a fluorinated pyridine core with bromine substituents at the 2 and 6 positions, enabling selective cross-coupling reactions. This electron-deficient heterocycle integrates readily into complex molecular architectures, offering enhanced stability under standard conditions.

Application

2,6-Dibromo-3-fluoropyridine serves as a versatile building block for the synthesis of fluorinated heterocycles and pharmaceutical intermediates. The ortho-bromine substituents enable palladium-catalyzed cross-coupling reactions, while the meta-fluorine facilitates nucleophilic aromatic substitution, offering orthogonal reactivity for sequential functionalization. Its bench-stable crystalline form simplifies handling and purification in multi-step syntheses.

Synthesis

  • Route1
    • null|null
      1133434-13-5
    • ~99%
    • In-stock
      2,6-Dibromo-3-fluoropyridine|CS-0063834
      41404-59-5

    References

    • Zhao, Zhongdong; Zhichkin, Pavel E.; Stafford, Douglas G.; Kropf, Jeffrey E.; BLOMGREN, Peter A.; Currie, Kevin S.; Lee, Seung H.; Mitchell, Scott A.; Xu, Jianjun; Schmitt, Aaron C. Patent: US2009/82330 A1, 2009 ; Location in patent: Page/Page column 37 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.7457
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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