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Structure of 877399-00-3
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(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is a chiral pyridine-based building block featuring a brominated heterocycle and a fluorinated aryl ether linkage. This configuration enables selective coupling in cross-coupling reactions, delivering complex scaffolds with enhanced solubility and metabolic stability. The pendant amine group facilitates downstream functionalization.
(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine serves as a key building block in the synthesis of kinase inhibitors and other bioactive heterocycles. The molecule features a chiral pyridine core with orthogonal functional groups: a bromide for palladium-catalyzed cross-coupling and a protected amine enabling sequential derivatization. Its bench-stable ether linkage and fluorinated aryl moiety enhance metabolic stability and target binding affinity. This compound facilitates efficient access to complex scaffolds through standard coupling protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: