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CS-W001157 4
Total: USD 88.00

(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

  • CAS No. 877399-00-3

  • Cat. No. CS-M0266
  • Molecule weight380.04
  • Purity≥98%
  • MDL No.MFCD18207061

*For research and further manufacturing use only, not for direct human use.

(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine|CS-M0266

Structure of 877399-00-3

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General Information

  • CAS No. 877399-00-3
  • Cat. No. CS-M0266
  • Purity ≥98%
  • MDL No. MFCD18207061
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₀BrCl₂FN₂O
  • Molecular Weight 380.04
  • Synonym(s) None
  • SMILES ClC(C([C@@H](C)OC1=C(N)N=CC(Br)=C1)=C(Cl)C=C2)=C2F

Description

(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine is a chiral pyridine-based building block featuring a brominated heterocycle and a fluorinated aryl ether linkage. This configuration enables selective coupling in cross-coupling reactions, delivering complex scaffolds with enhanced solubility and metabolic stability. The pendant amine group facilitates downstream functionalization.

Application

(R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine serves as a key building block in the synthesis of kinase inhibitors and other bioactive heterocycles. The molecule features a chiral pyridine core with orthogonal functional groups: a bromide for palladium-catalyzed cross-coupling and a protected amine enabling sequential derivatization. Its bench-stable ether linkage and fluorinated aryl moiety enhance metabolic stability and target binding affinity. This compound facilitates efficient access to complex scaffolds through standard coupling protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   5.0122
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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