Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate

Name: Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 87597-21-5
Cat. No. CS-0102752
Purity≥95%
MDL No.MFCD14706101

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate|CS-0102752

Structure of 87597-21-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 87597-21-5
Cat. No. CS-0102752
Purity ≥95%
MDL No. MFCD14706101
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₇Br₂N₃O₂
Molecular Weight 348.98
Synonym(s) Imidazo[1,2-a]pyrazine-2-carboxylic acid, 6,8-dibromo-, ethyl ester
SMILES O=C(C1=CN2C(C(Br)=NC(Br)=C2)=N1)OCC

Description

Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate is a sterically hindered, electron-deficient heterocyclic scaffold featuring two bromine substituents at the 6 and 8 positions. This configuration enhances its utility in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard conditions. The ester functionality provides synthetic handle for further derivatization.

Application

Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate serves as a versatile building block for constructing brominated heterocyclic scaffolds in medicinal chemistry. The dibromo substitution enables sequential cross-coupling reactions, while the ester group facilitates further functionalization. Its bench-stable nature and compatibility with palladium-catalyzed transformations make it well-suited for modular synthesis of complex imidazo[1,2-a]pyrazine derivatives used in target-oriented drug discovery.

Synthesis

Route1
- 70-23-5
- In-stock
  
  24241-18-7
- ~52%
- In-stock
  
  87597-21-5
References
- BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard Patent: WO2012/80234 A1, 2012 ; Location in patent: Page/Page column 45 ; WO 2012/080234 A1
Route2
- 65868-37-3
- In-stock
  
  24241-18-7
- ~%
- In-stock
  
  87597-21-5
References
- Sablayrolles; Cros; Milhavet; Rechenq; Chapat; Boucard; Serrano; McNeill Journal of Medicinal Chemistry, 1984 , vol. 27, # 2 p. 206 - 212

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 56.49
LogP 2.431
H_Acceptors 5
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Key Words

87597-21-5 sigma87597-21-5 manufacturer87597-21-5 price87597-21-5 structure87597-21-5 SDSbuy 87597-21-587597-21-5 supplier87597-21-5 uses87597-21-5 molecular weightprice of 87597-21-587597-21-5 chemical name formula of 87597-21-5

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Ethyl 6,8-dibromoimidazo[1,2-a]pyrazine-2-carboxylate

CAS No. 87597-21-5

Recommended Products