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CS-W001157 4
Total: USD 88.00

3-Hydroxypicolinic acid

  • CAS No. 874-24-8

  • Cat. No. CS-D1114
  • Purity≥97%
  • MDL No.MFCD00006294

*For research and further manufacturing use only, not for direct human use.

3-Hydroxypicolinic acid|CS-D1114

Structure of 874-24-8

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General Information

  • CAS No. 874-24-8
  • Cat. No. CS-D1114
  • Purity ≥97%
  • MDL No. MFCD00006294
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅NO₃
  • Molecular Weight 139.11
  • Synonym(s) 3-hydroxypyridine-2-carboxylic acid
  • SMILES O=C(C1=NC=CC=C1O)O

Description

Ligand for a variety of metal complexes including Hg(II), and Sm(III).

Application

3-Hydroxypicolinic acid serves as a versatile building block in medicinal chemistry and catalysis, offering both carboxylic acid and phenolic hydroxyl functionalities for selective derivatization. Its ortho-hydroxy-pyridine scaffold enables chelation with transition metals, facilitating use in asymmetric synthesis and metal complexation. The compound exhibits good bench stability and is compatible with common protecting group strategies, enabling efficient incorporation into heterocyclic scaffolds and API intermediates.

Synthesis

  • Route1

    References

    • Heterocyclic Communications, , vol. 9, # 5 p. 489 - 492
  • Route2

    References

    • Chemische Berichte, , vol. 90, p. 758,761
  • Route3

    References

    • Chemische Berichte, , vol. 90, p. 758,761

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   0.4854
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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