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CS-W001157 4
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tert-Butyl 5-bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate

  • CAS No. 873779-30-7

  • Cat. No. CS-W023016
  • Purity≥97%
  • MDL No.MFCD10566052

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 5-bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate|CS-W023016

Structure of 873779-30-7

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General Information

  • CAS No. 873779-30-7
  • Cat. No. CS-W023016
  • Purity ≥97%
  • MDL No. MFCD10566052
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₁BrN₂O₃
  • Molecular Weight 381.26
  • Synonym(s) 1'-Boc-5-Bromo-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
  • SMILES C(=O)(OC(C)(C)C)N1CCC3(CC1)C2=CC(=CC=C2NC3=O)Br

Synthesis

  • Route1

    References

    • MERCK and CO., INC. Patent: WO2008/144266 A1, 2008 ; Location in patent: Page/Page column 43 ; WO 2008/144266 A1
  • Route2
    • In-stock
      5-Bromoindolin-2-one|CS-W002616
      20870-78-4
    • null|null
      118753-70-1
    • ~%
    • In-stock
      tert-Butyl 5-bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate|CS-W023016
      873779-30-7

    References

    • Vachal, Petr; Miao, Shouwu; Pierce, Joan M.; Guiadeen, Deodial; Colandrea, Vincent J.; Wyvratt, Matthew J.; Salowe, Scott P.; Sonatore, Lisa M.; Milligan, James A.; Hajdu, Richard; Gollapudi, Anantha; Keohane, Carol A.; Lingham, Russell B.; Mandala, Suzanne M.; Demartino, Julie A.; Tong, Xinchun; Wolff, Michael; Steinhuebel, Dietrich; Kieczykowski, Gerard R.; Fleitz, Fred J.; Chapman, Kevin; Athanasopoulos, John; Adam, Gregory; Akyuz, Can D.; Jena, Dhirendra K.; Lusen, Jeffrey W.; Meng, Juncai; Stein, Benjamin D.; Xia, Lei; Sherer, Edward C.; Hale, Jeffrey J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 2945 - 2959
  • Route3

    References

    • WO2008/144266 A1, ; Page/Page column 43 ; WO 2008/144266 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   58.64
  • LogP   3.6699
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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