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CS-W001157 4
Total: USD 88.00

2-Bromo-4-chloroaniline

  • CAS No. 873-38-1

  • Cat. No. CS-W007350
  • Purity≥95%
  • MDL No.MFCD00041313

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4-chloroaniline|CS-W007350

Structure of 873-38-1

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General Information

  • CAS No. 873-38-1
  • Cat. No. CS-W007350
  • Purity ≥95%
  • MDL No. MFCD00041313
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrClN
  • Molecular Weight 206.47
  • Synonym(s) DISCONTINUED !2-Bromo-4-chloroaniline
  • SMILES NC1=CC=C(Cl)C=C1Br

Description

2-Bromo-4-chloroaniline features a dual halogen substitution pattern on the aniline scaffold, enabling precise functionalization in pharmaceutical and agrochemical synthesis. The ortho-bromo and para-chloro groups deliver enhanced reactivity in cross-coupling processes while maintaining stability under standard handling conditions.

Application

2-Bromo-4-chloroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The ortho-bromo and para-chloro substituents provide orthogonal functionalization handles, facilitating sequential transformations. Its bench stability and compatibility with standard reaction conditions make it ideal for constructing complex heterocyclic scaffolds and functionalized aryl systems in multi-step syntheses.

Synthesis

  • Route1
    • null|null
      106-47-8
    • ~10%
    • In-stock
      2-Bromo-4-chloroaniline|CS-W007350
      873-38-1

    References

    • Venkateswarlu, Katta; Suneel, Kanaparthy; Das, Biswanath; Reddy, Kuravallapalli Nagabhushana; Reddy, Thummala Sreenivasulu Synthetic Communications, 2009 , vol. 39, # 2 p. 215 - 219
  • Route2
    • Phenacetin Impurity 6|CS-1004960
      823-86-9
    • ~%
    • In-stock
      2-Bromo-4-chloroaniline|CS-W007350
      873-38-1

    References

    • Justus Liebigs Annalen der Chemie, , vol. 424, p. 300 Justus Liebigs Annalen der Chemie, , vol. 441, p. 303
  • Route3
    • N-Acety-2-bromo-4-chloroaniline|CS-0210287
      57045-85-9
    • ~%
    • In-stock
      2-Bromo-4-chloroaniline|CS-W007350
      873-38-1

    References

    • Chemische Berichte, , vol. 33, p. 2399

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.6847
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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