tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate

Name: tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate
Brand: ChemScene
Availability: InStock
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CAS No. 871022-62-7
Cat. No. CS-0047984
Molecule weight232.30
Purity≥97%
MDL No.MFCD11973738

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate|CS-0047984

Structure of 871022-62-7

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General Information

CAS No. 871022-62-7
Cat. No. CS-0047984
Purity ≥97%
MDL No. MFCD11973738
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₁FN₂O₂
Molecular Weight 232.30
Synonym(s) None
SMILES O=C(OC(C)(C)C)NCC1(F)CCNCC1

Description

tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate features a fluorinated piperidine scaffold with a bench-stable carbamate protecting group, enabling straightforward incorporation into complex molecular architectures. The electron-deficient fluorine enhances metabolic stability and modulates basicity, while the tert-butyl moiety ensures compatibility with standard deprotection protocols. This intermediate facilitates efficient access to bioactive fluorinated piperidines in medicinal chemistry campaigns.

Application

tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated piperidine scaffolds. The tert-butyl carbamate group provides excellent bench stability and ease of removal under mild acidic conditions, while the primary amine functionality facilitates diverse coupling reactions. Its compatibility with standard synthetic workflows supports rapid diversification in target-oriented synthesis.

Synthesis

Route1
- 871022-60-5
- ~57%
- In-stock
  
  871022-62-7
References
- Uchida, Chikara; Sone, Hiroki; Kawamura, Kiyoshi Patent: US2006/194842 A1, 2006 ; Location in patent: Page/Page column 37 ; US 20060194842 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 50.36
LogP 1.6028
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate

CAS No. 871022-62-7

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