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CS-W001157 4
Total: USD 88.00

3-(4-Fluorophenyl)-1H-pyrazole-5-carboxylic acid

  • CAS No. 870704-22-6

  • Cat. No. CS-0038334
  • Purity≥98%
  • MDL No.MFCD03420242
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-(4-Fluorophenyl)-1H-pyrazole-5-carboxylic acid|CS-0038334

Structure of 870704-22-6

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Description

This pyrazole carboxylic acid integrates a 4-fluorophenyl group at the 3-position, delivering enhanced electron-withdrawing character and improved metabolic stability. The carboxylic acid functionality enables direct coupling or salt formation, supporting downstream derivatization in medicinal chemistry campaigns.

Application

3-(4-Fluorophenyl)-1H-pyrazole-5-carboxylic acid serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, offering a well-defined scaffold for drug discovery programs. Its carboxylic acid functionality enables direct derivatization via amide coupling, esterification, or metal-catalyzed transformations. The 4-fluorophenyl substituent enhances metabolic stability and modulates electronic properties, while the pyrazole core provides favorable hydrogen-bonding capacity and planar geometry. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.

General Information

  • CAS No. 870704-22-6
  • Cat. No. CS-0038334
  • Purity ≥98%
  • MDL No. MFCD03420242
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇FN₂O₂
  • Molecular Weight 206.17
  • Synonym(s) None
  • SMILES C1=C(C=CC(=C1)F)C2=CC(=NN2)C(=O)O

Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.914
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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