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CS-W001157 4
Total: USD 88.00

Boc-Val-Cit-PAB-PNP

  • CAS No. 870487-10-8

  • Cat. No. CS-0115065
  • Purity≥95%
  • MDL No.MFCD22417105

*For research and further manufacturing use only, not for direct human use.

Boc-Val-Cit-PAB-PNP|CS-0115065

Structure of 870487-10-8

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General Information

  • CAS No. 870487-10-8
  • Cat. No. CS-0115065
  • Purity ≥95%
  • MDL No. MFCD22417105
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₄₀N₆O₁₀
  • Molecular Weight 644.67
  • Synonym(s) None
  • SMILES O=C(OC1=CC=C(C=C1)[N+]([O-])=O)OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OC(C)(C)C)=O)=O)=O

Description

Boc-Val-Cit-PAB-PNP is a cleavable linker designed for antibody-drug conjugates, featuring a para-aminobenzyl alcohol (PAB) spacer and a phenylalanine-based cleavage site. This construct enables efficient intracellular release of payload following proteolytic processing, combining stability in circulation with targeted activation in lysosomal environments.

Application

Boc-Val-Cit-PAB-PNP serves as a stable, bench-ready linker for antibody-drug conjugates, enabling efficient conjugation via the PAB moiety. The Val-Cit dipeptide provides protease-sensitive cleavage, while the Boc group ensures stability during synthesis and storage. Its orthogonal functionalization profile facilitates reliable coupling in standard bioconjugation workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   230.32
  • LogP   3.7315
  • H_Acceptors   10
  • H_Donors   5
  • Rotatable_Bonds   14

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