Boc-Val-Ala-PAB-PNP

Name: Boc-Val-Ala-PAB-PNP
Brand: ChemScene
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CAS No. 1884578-00-0
Cat. No. CS-0119068
Purity≥98%
MDL No.MFCD28557281

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 1884578-00-0

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General Information

CAS No. 1884578-00-0
Cat. No. CS-0119068
Purity ≥98%
MDL No. MFCD28557281
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₇H₃₄N₄O₉
Molecular Weight 558.58
Synonym(s) None
SMILES CC([C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(NC1=CC=C(C=C1)COC(OC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)C)=O)C

Description

Boc-Val-Ala-PAB-PNP serves as a key intermediate in peptide synthesis, featuring a protected N-terminal valine and an activated C-terminal PAB-PNP moiety. This combination enables efficient coupling reactions under standard conditions, with the PNP group facilitating rapid deprotection and purification. The Boc protection ensures stability during manipulation, while the Ala residue provides optimal spacing for conjugation. Ideal for solid-phase and solution-phase workflows, this reagent streamlines access to complex peptide architectures.

Application

Boc-Val-Ala-PAB-PNP serves as a versatile building block for the synthesis of peptide-based conjugates and prodrugs. The Boc group provides reliable N-terminal protection, while the Val-Ala dipeptide sequence enables enzymatic cleavage in biological systems. The PAB-PNP moiety offers a robust linker for site-specific attachment to antibodies or solid supports, facilitating efficient conjugation via nucleophilic displacement. This compound exhibits excellent bench stability, compatibility with standard peptide coupling protocols, and ease of purification, making it ideal for modular assembly of targeted therapeutics.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

TPSA 175.2
LogP 4.3029
H_Acceptors 9
H_Donors 3
Rotatable_Bonds 10

Other Classifications

Life Science Linker Cleavable Linkers

Life Science Linker Peptide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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Boc-Val-Ala-PAB-PNP

CAS No. 1884578-00-0

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