Fmoc-Val-Ala-PAB-PNP

Name: Fmoc-Val-Ala-PAB-PNP
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CAS No. 1394238-92-6
Cat. No. CS-0119705
Purity≥96%
MDL No.MFCD28557283

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1394238-92-6
Cat. No. CS-0119705
Purity ≥96%
MDL No. MFCD28557283
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₇H₃₆N₄O₉
Molecular Weight 680.70
Synonym(s) None
SMILES [O-][N+](C(C=C1)=CC=C1OC(OCC(C=C2)=CC=C2NC([C@H](C)NC([C@H](C(C)C)NC(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)=O)=O)=O)=O

Description

Fmoc-Val-Ala-PAB-PNP is a specialized cleavable linker for solid-phase peptide synthesis, featuring a para-nitrophenyl (PNP) leaving group and a pivaloyl-protected amine. This design enables efficient on-resin deprotection under mild conditions, facilitating rapid release of target peptides without side reactions. The PAB spacer enhances solubility and stability during conjugation processes.

Application

Fmoc-Val-Ala-PAB-PNP serves as a robust linker for antibody-drug conjugates, enabling efficient site-specific payload attachment. The PAB (para-aminobenzyl) spacer provides cleavability under mild acidic conditions, while the PNP (p-nitrophenyl) leaving group facilitates reliable conjugation chemistry. This construct combines bench stability with predictable reactivity in standard bioconjugation workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 175.2
LogP 6.3169
H_Acceptors 9
H_Donors 3
Rotatable_Bonds 12

Other Classifications

Life Science Linker Cleavable Linkers

Life Science Linker Fmoc PEG

Life Science Linker Peptide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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Fmoc-Val-Ala-PAB-PNP

CAS No. 1394238-92-6

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