Boc-Val-Cit-PAB

Name: Boc-Val-Cit-PAB
Brand: ChemScene
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CAS No. 870487-09-5
Cat. No. CS-0114767
Molecule weight479.57
Purity≥97%
MDL No.MFCD22200277

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 870487-09-5
Cat. No. CS-0114767
Purity ≥97%
MDL No. MFCD22200277
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₃₇N₅O₆
Molecular Weight 479.57
Synonym(s) None
SMILES OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OC(C)(C)C)=O)=O)=O

Description

Boc-Val-Cit-PAB is a cleavable linker designed for antibody-drug conjugate (ADC) applications. This moiety integrates a valine-citrulline dipeptide with a para-aminobenzyl carbamate (PAB) spacer, enabling efficient intracellular release of payload upon enzymatic cleavage. The Boc group ensures stability during circulation while allowing controlled drug liberation in target tissues.

Application

Boc-Val-Cit-PAB serves as a stable, bench-ready linker for antibody-drug conjugates, enabling efficient conjugation via hydrazine ligation. The Val-Cit dipeptide provides protease-sensitive cleavage in lysosomal environments, while the PAB (para-aminobenzoyl) moiety offers a robust handle for site-specific attachment to payloads. Boc protection ensures stability during synthesis and purification, facilitating straightforward handling and high yields in standard peptide coupling protocols.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 171.88
LogP 1.6
H_Acceptors 6
H_Donors 6
Rotatable_Bonds 11

Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker Cleavable Linkers

Life Science Linker Peptide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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Boc-Val-Cit-PAB

CAS No. 870487-09-5

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