Boc-Val-Cit-PAB

Name: Boc-Val-Cit-PAB
Brand: ChemScene
Availability: InStock
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CAS No. 870487-09-5
Cat. No. CS-0114767
Purity≥97%
MDL No.MFCD22200277

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HazMat Fee

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 870487-09-5

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Description

Boc-Val-Cit-PAB is a cleavable linker designed for antibody-drug conjugate (ADC) applications. This moiety integrates a valine-citrulline dipeptide with a para-aminobenzyl carbamate (PAB) spacer, enabling efficient intracellular release of payload upon enzymatic cleavage. The Boc group ensures stability during circulation while allowing controlled drug liberation in target tissues.

Application

Boc-Val-Cit-PAB serves as a stable, bench-ready linker for antibody-drug conjugates, enabling efficient conjugation via hydrazine ligation. The Val-Cit dipeptide provides protease-sensitive cleavage in lysosomal environments, while the PAB (para-aminobenzoyl) moiety offers a robust handle for site-specific attachment to payloads. Boc protection ensures stability during synthesis and purification, facilitating straightforward handling and high yields in standard peptide coupling protocols.

General Information

CAS No. 870487-09-5
Cat. No. CS-0114767
Purity ≥97%
MDL No. MFCD22200277
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₃H₃₇N₅O₆
Molecular Weight 479.57
Synonym(s) None
SMILES OCC(C=C1)=CC=C1NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OC(C)(C)C)=O)=O)=O

Computational Chemistry Data

TPSA 171.88
LogP 1.6
H_Acceptors 6
H_Donors 6
Rotatable_Bonds 11

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker Cleavable Linkers

Life Science Linker Peptide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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Boc-Val-Cit-PAB

CAS No. 870487-09-5

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