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CS-W001157 4
Total: USD 88.00

2-Chloroethanamine hydrochloride

  • CAS No. 870-24-6

  • Cat. No. CS-W013617
  • Purity≥98%
  • MDL No.MFCD00012887

*For research and further manufacturing use only, not for direct human use.

2-Chloroethanamine hydrochloride|CS-W013617

Structure of 870-24-6

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General Information

  • CAS No. 870-24-6
  • Cat. No. CS-W013617
  • Purity ≥98%
  • MDL No. MFCD00012887
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂H₇Cl₂N
  • Molecular Weight 115.99
  • Synonym(s) 2-Chloroethylammonium chloride
  • SMILES Cl.ClCCN

Description

Glycolaldehyde dimer may be used in the synthesis of 3,4-diaza-2-hexene-1,6-diol, which can undergo hydrogenation to form 1,2-bis(2-hydroxyethyl)hydrazine. It undergoes cycloaddition with 2,3-dihydrofuran in the presence of a chiral catalyst to form fused bicyclic tetrahydrofuran (bis-THF) alcohol, a key moiety of HIV protease inhibitors.

Application

2-Chloroethanamine hydrochloride serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient construction of nitrogen-containing heterocycles and peptide analogs. Its reactive chloroethyl group facilitates alkylation reactions under mild conditions, while the amine functionality offers facile derivatization. The hydrochloride salt form ensures excellent bench stability, ease of handling, and compatibility with standard aqueous workups, making it well-suited for use in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • Ethanolamine hydrochloride|CS-0088236
      2002-24-6
    • ~99%
    • In-stock
      2-Chloroethanamine hydrochloride|CS-W013617
      870-24-6

    References

    • Laduranty, Joelle; Lion, Claude; Mesnard, Daniele; Miginiac, Leone Bulletin des Societes Chimiques Belges, 1984 , vol. 93, # 10 p. 903 - 912
  • Route2
    • null|null
      7719-09-7
    • Ethanolamine hydrochloride|CS-0088236
      2002-24-6
    • null|null
      68-12-2
    • ~97%
    • In-stock
      2-Chloroethanamine hydrochloride|CS-W013617
      870-24-6

    References

    • Sumitomo Chemical Company, Limited Patent: US3956385 A1, 1976 ;
  • Route3
    • null|null
      141-43-5
    • ~%
    • In-stock
      2-Chloroethanamine hydrochloride|CS-W013617
      870-24-6

    References

    • Helvetica Chimica Acta, , vol. 77, # 5 p. 1241 - 1255

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS08
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H290-H314-H341
Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.6057
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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