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CS-W001157 4
Total: USD 88.00

N-Boc-2-chloroethylamine

  • CAS No. 71999-74-1

  • Cat. No. CS-W004916
  • Purity≥98%
  • MDL No.MFCD04004074

*For research and further manufacturing use only, not for direct human use.

N-Boc-2-chloroethylamine|CS-W004916

Structure of 71999-74-1

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General Information

  • CAS No. 71999-74-1
  • Cat. No. CS-W004916
  • Purity ≥98%
  • MDL No. MFCD04004074
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄ClNO₂
  • Molecular Weight 179.64
  • Synonym(s) tert-Butyl N-(2-chloroethyl)carbamate
  • SMILES O=C(OC(C)(C)C)NCCCl

Description

N-Boc-2-chloroethylamine delivers a protected amine handle for nucleophilic substitution, enabling direct coupling to electrophiles without side reactions. The Boc group ensures stability under basic conditions and facilitates selective deprotection during late-stage functionalization. This chloroethyl moiety integrates readily into bioactive scaffolds, offering controlled reactivity in synthetic pathways.

Synthesis

  • Route1
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • 2-Chloroethanamine hydrochloride Ifosfamide  Impurity|CS-0229451
      870-24-6
    • ~97%
    • In-stock
      N-Boc-2-chloroethylamine|CS-W004916
      71999-74-1

    References

    • Sagi, Kazuyuki; Nakagawa, Tadakiyo; Yamanashi, Masahiro; Makino, Shingo; Takahashi, Mitsuo; Takayanagi, Masaru; Takenaka, Kaoru; Suzuki, Nobuyasu; Oono, Seiji; Kataoka, Noriyasu; Ishikawa, Kohki; Shima, Sayaka; Fukuda, Yumiko; Kayahara, Takashi; Takehana, Shunji; Shima, Yoichiro; Tashiro, Kazumi; Yamamoto, Hiroshi; Yoshimoto, Ryota; Iwata, Seinosuke; Tsuji, Takashi; Sakurai, Kuniya; Shoji, Masataka Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1845 - 1857
  • Route2
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      689-98-5
    • ~%
    • In-stock
      N-Boc-2-chloroethylamine|CS-W004916
      71999-74-1

    References

    • US6410576 B1, ; US 6410576 B1
  • Route3
    • null|null
      41840-28-2
    • null|null
      689-98-5
    • ~90%
    • In-stock
      N-Boc-2-chloroethylamine|CS-W004916
      71999-74-1

    References

    • Tanaka, Ken-Ichi; Yoshifuji, Shigeyuki; Nitta, Yoshihiro Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 8 p. 3125 - 3129

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H314
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P302+P352-P304+P340-P330-P362+P364-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.7499
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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