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CS-W001157 4
Total: USD 88.00

2,5-Dimethoxypyridine

  • CAS No. 867267-24-1

  • Cat. No. CS-0044152
  • Purity≥98%
  • MDL No.MFCD12546620

*For research and further manufacturing use only, not for direct human use.

2,5-Dimethoxypyridine|CS-0044152

Structure of 867267-24-1

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General Information

  • CAS No. 867267-24-1
  • Cat. No. CS-0044152
  • Purity ≥98%
  • MDL No. MFCD12546620
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NO₂
  • Molecular Weight 139.15
  • Synonym(s) None
  • SMILES COC1=CN=C(OC)C=C1

Description

2,5-Dimethoxypyridine offers a sterically hindered, electron-rich pyridine scaffold ideal for transition metal-catalyzed cross-couplings. The para-oriented methoxy groups enhance solubility and stabilize reactive intermediates under standard conditions. This bench-stable heterocycle integrates readily into complex molecular architectures.

Application

2,5-Dimethoxypyridine serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient construction of bioactive heterocycles. Its ortho-dimethoxy substitution pattern provides enhanced stability and facilitates electrophilic aromatic substitution or transition-metal-catalyzed coupling reactions. The molecule exhibits favorable functional group tolerance and simplifies purification due to its bench-stable nature, making it well-suited for scalable synthesis workflows and API intermediate development.

Synthesis

  • Route1
    • In-stock
      5-Hydroxy-2-methoxylpyridine|CS-W005101
      51834-97-0
    • null|null
      74-88-4
    • ~88%
    • In-stock
      2,5-Dimethoxypyridine|CS-0044152
      867267-24-1

    References

    • Mahiout, Zahia; Lomberget, Thierry; Goncalves, Sylvie; Barret, Roland Organic and Biomolecular Chemistry, 2008 , vol. 6, # 8 p. 1364 - 1376

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   31.35
  • LogP   1.0988
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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