4-Chloro-5-methoxypyridin-2-amine

Name: 4-Chloro-5-methoxypyridin-2-amine
Brand: ChemScene
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CAS No. 867131-26-8
Cat. No. CS-0050908
Purity≥95%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-Chloro-5-methoxypyridin-2-amine|CS-0050908

Structure of 867131-26-8

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General Information

CAS No. 867131-26-8
Cat. No. CS-0050908
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇ClN₂O
Molecular Weight 158.59
Synonym(s) 2-amino-4-chloro-5-methoxypyridine
SMILES COC1=CN=C(N)C=C1Cl

Description

4-Chloro-5-methoxypyridin-2-amine features a pyridine core functionalized with chlorine and methoxy groups flanking a primary amine, enabling direct incorporation into diverse heterocyclic scaffolds. This bench-stable derivative exhibits enhanced solubility in polar solvents, facilitating its use in cross-coupling reactions and medicinal chemistry campaigns requiring nitrogen-rich frameworks.

Application

4-Chloro-5-methoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. The chloro group facilitates Suzuki, Stille, and Buchwald–Hartwig couplings, while the methoxy and amine functionalities offer orthogonal reactivity for further functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 48.14
LogP 1.3258
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Chloro-5-methoxypyridin-2-amine

CAS No. 867131-26-8

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