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CS-W001157 4
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Fmoc-Glu(Otbu)-Gly-OH

  • CAS No. 866044-63-5

  • Cat. No. CS-0886016
  • Molecule weight482.53
  • Purity≥98%
  • MDL No.MFCD30475796

*For research and further manufacturing use only, not for direct human use.

Fmoc-Glu(Otbu)-Gly-OH|CS-0886016

Structure of 866044-63-5

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General Information

  • CAS No. 866044-63-5
  • Cat. No. CS-0886016
  • Purity ≥98%
  • MDL No. MFCD30475796
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₃₀N₂O₇
  • Molecular Weight 482.53
  • Synonym(s) None
  • SMILES CC(C)(C)OC(CC[C@@H](C(NCC(O)=O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O

Description

Fmoc-Glu(Otbu)-Gly-OH is a protected dipeptide building block designed for solid-phase peptide synthesis. The Fmoc group enables efficient N-terminal deprotection under mild basic conditions, while the OtBu side chain on glutamic acid provides steric shielding and enhanced solubility. This combination ensures high coupling efficiency and minimizes epimerization during chain elongation.

Application

Fmoc-Glu(Otbu)-Gly-OH serves as a key dipeptide building block in solid-phase peptide synthesis, enabling efficient N-terminal protection and side-chain masking. The Fmoc group allows for orthogonal deprotection under mild basic conditions, while the OtBu ester selectively protects the glutamic acid side chain. This combination provides excellent stability during handling and purification, facilitates high-yielding coupling reactions, and supports sequence flexibility in the synthesis of biologically active peptides and peptidomimetics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P362+P364

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Computational Chemistry Data

  • TPSA   131.03
  • LogP   3.2164
  • H_Acceptors   6
  • H_Donors   3
  • Rotatable_Bonds   9

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