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CS-W001157 4
Total: USD 88.00

1-(difluoromethyl)-1H-pyrazol-3-amine

  • CAS No. 865663-99-6

  • Cat. No. CS-0270792
  • Molecule weight133.10
  • Purity≥95%
  • MDL No.MFCD09834153

*For research and further manufacturing use only, not for direct human use.

1-(difluoromethyl)-1H-pyrazol-3-amine|CS-0270792

Structure of 865663-99-6

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General Information

  • CAS No. 865663-99-6
  • Cat. No. CS-0270792
  • Purity ≥95%
  • MDL No. MFCD09834153
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅F₂N₃
  • Molecular Weight 133.10
  • Synonym(s) None
  • SMILES FC(F)N1C=CC(N)=N1

Description

1-(difluoromethyl)-1H-pyrazol-3-amine features a strategically positioned difluoromethyl group that enhances metabolic stability and membrane permeability. This electron-deficient pyrazole scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for targeted kinase inhibitors and CNS-active compounds.

Application

1-(Difluoromethyl)-1H-pyrazol-3-amine serves as a valuable building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group adjacent to a nitrogen-rich heterocyclic core. Its functionality facilitates nucleophilic substitution and coupling reactions, with demonstrated utility in constructing bioactive scaffolds. The compound exhibits good bench stability and compatibility with common reaction conditions, supporting efficient synthesis and purification workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   44.57
  • LogP   0.69077
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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