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1-[(Tert-butoxy)carbonyl]-3-hydroxyazetidine-3-carboxylic acid

  • CAS No. 1035351-06-4

  • Cat. No. CS-0052692
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-[(Tert-butoxy)carbonyl]-3-hydroxyazetidine-3-carboxylic acid|CS-0052692

Structure of 1035351-06-4

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General Information

  • CAS No. 1035351-06-4
  • Cat. No. CS-0052692
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₅NO₅
  • Molecular Weight 217.22
  • Synonym(s) 1-{[(1,1-diMethylethyl)oxy]carbonyl}-3-hydroxyazetidine-3-carboxylic acid
  • SMILES CC(C)(C)OC(=O)N1CC(O)(C1)C(O)=O

Description

This azetidine derivative features a tert-butoxycarbonyl-protected amine and a hydroxyl group on the ring, enabling direct incorporation into peptide synthesis. The protected amine facilitates selective functionalization, while the hydroxy group provides a handle for further derivatization or conjugation under standard conditions.

Application

1-[(Tert-butoxy)carbonyl]-3-hydroxyazetidine-3-carboxylic acid serves as a versatile building block for the synthesis of azetidinone-containing scaffolds and bioactive heterocycles. The protected hydroxyl and carboxylic acid functionalities enable orthogonal transformations, while the strained azetidine ring facilitates nucleophilic ring-opening reactions. Its bench-stable tert-butyl carbamate group simplifies purification and allows sequential functionalization in multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   87.07
  • LogP   0.0528
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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