2-(2,2-Difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride

Name: 2-(2,2-Difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride
Brand: ChemScene
Availability: InStock
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CAS No. 865352-01-8
Cat. No. CS-0199249
Purity≥97%
MDL No.None

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Type	HazMat Fee
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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-(2,2-Difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride|CS-0199249

Structure of 865352-01-8

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Description

This sulfonyl chloride features a trifluoromethyl group at the para position and a difluoroethoxy substituent, delivering enhanced electron-withdrawing character and improved solubility. The combination enables efficient coupling in synthetic workflows, particularly for fluorinated aromatic systems requiring stable, reactive intermediates under standard conditions.

Application

2-(2,2-Difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride serves as a versatile sulfonyl chloride building block for constructing sulfonamide derivatives. Its reactivity is enhanced by the electron-withdrawing trifluoromethyl and difluoroethoxy substituents, which improve electrophilicity at the sulfonyl center. The compound exhibits good bench stability and facilitates clean coupling with amines under mild conditions, enabling efficient access to fluorinated sulfonamides used in medicinal chemistry and agrochemical research.

General Information

CAS No. 865352-01-8
Cat. No. CS-0199249
Purity ≥97%
MDL No. None
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₆ClF₅O₃S
Molecular Weight 324.65
Synonym(s) 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzenesulfonyl chloride
SMILES O=S(C1=C(C(F)(F)F)C=CC=C1OCC(F)F)(Cl)=O

Computational Chemistry Data

TPSA 43.37
LogP 3.2768
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 4

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Other Classifications

Building Blocks Functional Group Sulfonyl Chloride

Building Blocks Functional Group Ether

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-(2,2-Difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride

CAS No. 865352-01-8

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