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Structure of 864771-44-8
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tert-Butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate is a bench-stable boronate ester featuring a strategically positioned indazole core. This reagent integrates seamlessly into Suzuki-Miyaura coupling protocols, enabling efficient C–C bond formation under mild conditions. The tetramethyl-1,3,2-dioxaborolane moiety enhances stability and solubility, while the tert-butyl carbamate group provides convenient protection and orthogonal deprotection options.
tert-Butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate serves as a versatile boron-containing building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylboronate group enables efficient palladium-catalyzed coupling with aryl and vinyl halides under mild conditions. The indazole core provides a rigid, bioactive scaffold commonly found in pharmaceuticals, while the tert-butyl ester offers bench stability and ease of purification. Functions as a key intermediate in the synthesis of functionalized heterocycles and drug candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: