Lot numbers can be found on the outside label of a product:
1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid
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CAS No. 86447-11-2
- Cat. No. CS-W018879
- Purity≥97%
- MDL No.MFCD11519232
*For research and further manufacturing use only, not for direct human use.
Structure of 86447-11-2
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General Information
- CAS No. 86447-11-2
- Cat. No. CS-W018879
- Purity ≥97%
- MDL No. MFCD11519232
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₇NO₄
- Molecular Weight 227.26
- Synonym(s) 1-(tert-butoxycarbonyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid
- SMILES O=C(C1=CCCN(C(OC(C)(C)C)=O)C1)O
Description
1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid serves as a stable, bench-ready precursor for functionalized tetrahydropyridine scaffolds. The Boc group enables selective deprotection under mild acidic conditions, while the carboxylic acid moiety facilitates conjugation via amide or ester linkages. This compound integrates readily into synthetic sequences requiring nitrogen-containing heterocycles with controlled reactivity and enhanced solubility in organic media.
Application
1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid serves as a versatile building block for the synthesis of substituted tetrahydropyridine scaffolds prevalent in medicinal chemistry. The Boc group provides excellent stability and orthogonal deprotection compatibility, enabling controlled functionalization at the nitrogen. The carboxylic acid moiety facilitates coupling reactions with amines and alcohols under standard conditions, supporting efficient access to diverse analogs. Its bench-stable nature and predictable reactivity make it ideal for multi-step syntheses and process development.
Synthesis
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Route1
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126114-09-8 - ~98%
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In-stock
86447-11-2
References
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Knapp; Zhao Organic letters, 2000 , vol. 2, # 25 p. 4037 - 4040
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Route2
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In-stock
24424-99-5 - ~%
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In-stock
86447-11-2
References
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Organic letters, , vol. 2, # 25 p. 4037 - 4040
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Route3
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In-stock
125097-83-8 - ~99%
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In-stock
86447-11-2
References
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Napolitano, Carmela; Borriello, Manuela; Cardullo, Francesca; Donati, Daniele; Paio, Alfredo; Manfredini, Stefano Tetrahedron, 2010 , vol. 66, # 29 p. 5492 - 5497
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Safety Information
Download SDS|
GHS Pictogram :
N/A
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GHS No : N/A
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Signal Word : N/A
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : N/A
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Precautionary Statements : N/A
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Quality Control
Computational Chemistry Data
- TPSA 66.84
- LogP 1.6382
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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