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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-6-(trifluoromethyl)quinazoline

  • CAS No. 864291-30-5

  • Cat. No. CS-W021509
  • Molecule weight267.04
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-6-(trifluoromethyl)quinazoline|CS-W021509

Structure of 864291-30-5

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General Information

  • CAS No. 864291-30-5
  • Cat. No. CS-W021509
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₃Cl₂F₃N₂
  • Molecular Weight 267.04
  • Synonym(s) Quinazoline, 2,4-dichloro-6-(trifluoromethyl)-
  • SMILES FC(C1=CC2=C(Cl)N=C(Cl)N=C2C=C1)(F)F

Description

2,4-Dichloro-6-(trifluoromethyl)quinazoline is a bench-stable heterocyclic scaffold featuring electron-deficient aryl character, enabling efficient coupling in cross-coupling and nucleophilic substitution reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the dichloro substitution pattern provides regioselective reactivity for functionalization in medicinal chemistry and materials science applications.

Application

2,4-Dichloro-6-(trifluoromethyl)quinazoline serves as a versatile building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and other bioactive heterocycles. Its reactive chlorines facilitate nucleophilic substitution under mild conditions, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The compound exhibits good bench stability and compatibility with standard coupling protocols, making it well-suited for iterative synthetic campaigns in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   3.9554
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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