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CS-W001157 4
Total: USD 88.00

DOV-216,303

  • CAS No. 86215-36-3

  • Cat. No. CS-0052897
  • Molecule weight264.58
  • Purity≥97%
  • MDL No.MFCD06407666

*For research and further manufacturing use only, not for direct human use.

DOV-216,303|CS-0052897

Structure of 86215-36-3

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General Information

  • CAS No. 86215-36-3
  • Cat. No. CS-0052897
  • Purity ≥97%
  • MDL No. MFCD06407666
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂Cl₃N
  • Molecular Weight 264.58
  • Synonym(s) None
  • SMILES ClC1=C(C=C(C23CC2CNC3)C=C1)Cl.Cl

Description

Inhibiting dopamine reuptake and serotonergic transmission, DOV 216,303 (CAS 86215-36-3) demonstrates potent modulation of monoamine neurotransmission in preclinical neuropharmacology models.

Synthesis

  • Route1
    • 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione|CS-1143817
      66504-44-7
    • ~%
    • DOV-216,303|CS-0052897
      86215-36-3

    References

    • Hagen, Eric J.; Halloran, Kevin Patent: US2007/43100 A1, 2007 ; Location in patent: Page/Page column 10-11 ;
  • Route2
    • null|null
      877397-17-6
    • ~%
    • DOV-216,303|CS-0052897
      86215-36-3

    References

    • EUTHYMIC BIOSCIENCE, INC.; MCKINNEY, Anthony, Alexander; BYMASTER, Frank; PISKORSKI, Walter Patent: WO2012/75473 A1, 2012 ;
  • Route3

    References

    • EUTHYMIC BIOSCIENCE, INC.; MCKINNEY, Anthony, Alexander; BYMASTER, Frank; PISKORSKI, Walter Patent: WO2012/75473 A1, 2012 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H319
Precautionary Statements : P264-P270-P280-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   3.2761
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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